Will Ferrell

Megamind (voice)

Brad Pitt

Metro Man (voice)

Tina Fey

Roxanne Ritchi (voice)

Jonah Hill

Tighten (voice)

David Cross

Minion (voice)

Ben Stiller

Bernard (voice)

Justin Theroux

Megaminds's Father (voice)

Jessica Schulte

Megamind's Mother (voice)

Tom McGrath

Lord Scott / Prison Guard (voice)

Emily Nordwind

Lady Scott (voice)

J.K. Simmons

Warden (voice)

Ella Stiller

Schoolchild (voice)