Frank Welker

Scooby-Doo / Fred Jones (voice)

Casey Kasem

Shaggy Rogers (voice)

Mindy Cohn

Velma Dinkley (voice)

Grey DeLisle

Daphne Blake (voice)

Ron Perlman

Captain Skunkbeard / Biff Wellington (voice)

Freddy Rodríguez

Rupert Garcia (voice)

Tim Conway

Skip Jones (voice)

Edie McClurg

Peggy Jones / Sea Salt Sally (voice)

Kathy Najimy

Sunny St. Cloud (voice)

Arsenio Hall

Captain Crothers (voice)

Dan Castellaneta

Mr. Mysterio / Woodenleg Wally (voice)